Fusion of the dendritic cell-targeting chemokine MIP3α to melanoma antigen Gp100 in a therapeutic DNA vaccine significantly enhances immunogenicity and survival …
JT Gordy, K Luo, H Zhang, A Biragyn… - … for immunotherapy of …, 2016 - Springer
… have been shown to direct antigen to immature DCs via CCR6 … tumor-associated antigen
gp100 has been analyzed in a … -only vaccine elicited a moderate vaccine-specific CD8+ T-cell …
gp100 has been analyzed in a … -only vaccine elicited a moderate vaccine-specific CD8+ T-cell …
[HTML][HTML] Enhanced anti-tumor therapeutic efficacy of DNA vaccine by fusing the E7 gene to BAFF in treating human papillomavirus-associated cancer
CC Wu, FC Wu, YT Hsu, YC Hsiao, YC Yang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… by delivering tumor-associated antigen-expressing vectors … most crucial effectors in inducing
antitumor immunity. We first … receptors (eg CCR1, CCR5, and CCR6), Toll-like receptors (eg …
antitumor immunity. We first … receptors (eg CCR1, CCR5, and CCR6), Toll-like receptors (eg …
Treatment with an immature dendritic cell-targeting vaccine supplemented with IFN-α and an inhibitor of DNA methylation markedly enhances survival in a murine …
… The chemokine MIP-3α (CCL20) binds to CCR6 on immature … in developing vaccine-derived
anti-tumor immunity in preclinical … The addition of more tumor associated antigens and/or …
anti-tumor immunity in preclinical … The addition of more tumor associated antigens and/or …
Extended protection capabilities of an immature dendritic-cell targeting malaria sporozoite vaccine
K Luo, F Zavala, J Gordy, H Zhang, RB Markham - Vaccine, 2017 - Elsevier
… vaccinations, three weeks apart, elicited extraordinarily high, MIP3α-dependent antibody
responses. MIP3α was able to target the vaccine to the CCR6 … is the most potent attractant of …
responses. MIP3α was able to target the vaccine to the CCR6 … is the most potent attractant of …
Targeting tumor-associated macrophages to increase the efficacy of immune checkpoint inhibitors: a glimpse into novel therapeutic approaches for metastatic …
C Ceci, MG Atzori, PM Lacal, G Graziani - Cancers, 2020 - mdpi.com
… in the failure of the anti-tumor immune surveillance, as well … ; IL-10 and glucocorticoids can
elicit the M2c form of active … complex, impairing effector T-cell-mediated responses to tumor …
elicit the M2c form of active … complex, impairing effector T-cell-mediated responses to tumor …
… MODEL OF A DENDRITIC CELL-TARGETING THERAPEUTIC DNA VACCINE AND ENHANCEMENT OF ITS ACTIVITY BY CO-TREATMENT WITH ANTIBODIES TO …
J Gordy - 2016 - jscholarship.library.jhu.edu
… to play a role in anti-tumor immunity. Antibodies specific to … and reinfusion can induce T-cell
mediated regression of melanoma … tumor-associated antigen gp100 has been analyzed in a …
mediated regression of melanoma … tumor-associated antigen gp100 has been analyzed in a …
Dendritic cell targeted Ccl3-and Xcl1-fusion DNA vaccines differ in induced immune responses and optimal delivery site
A Lysén, R Braathen, A Gudjonsson, DY Tesfaye… - Scientific Reports, 2019 - nature.com
… Ccl3-fusion vaccines, and resulted in strong cytotoxic T cell … To test the protective efficacy of
the targeted vaccines, we utilized … that pDCs can enhance CD8 T cell responses induced by …
the targeted vaccines, we utilized … that pDCs can enhance CD8 T cell responses induced by …
IFN-α and 5-Aza-2'-deoxycytidine enhance the anti-tumor efficacy of a dendritic-cell targeting MIP3a-Gp100-Trp2 DNA vaccine by affecting T-cell recruitment and …
JT Gordy, K Luo, RB Markham - Biorxiv, 2019 - biorxiv.org
… the vaccine antigen to the CC chemokine receptor type 6 (CCR6… in developing vaccine-derived
anti-tumor immunity in preclinical … The addition of more tumor associated antigens and/or …
anti-tumor immunity in preclinical … The addition of more tumor associated antigens and/or …
A chemokine-fusion vaccine targeting immature dendritic cells elicits elevated antibody responses to malaria sporozoites in infant macaques
K Luo, JT Gordy, F Zavala, RB Markham - Scientific reports, 2021 - nature.com
… on the protective efficacy in a mouse challenge model of a vaccine … vaccine construct
has two functions: (1) to target the vaccine antigen to the C–C Motif Chemokine Receptor 6 (CCR6) …
has two functions: (1) to target the vaccine antigen to the C–C Motif Chemokine Receptor 6 (CCR6) …
A vaccine composed of antigen fused to a ligand for a receptor on immature dendritic cells elicits elevated antibody responses to malaria sporozoites in infant …
K Luo, JT Gordy, F Zavala, RB Markham - bioRxiv, 2019 - biorxiv.org
… on the protective efficacy in a mouse challenge model of a vaccine … vaccine construct
has two functions: 1) To target the vaccine antigen to the CC Motif Chemokine Receptor 6 (CCR6) …
has two functions: 1) To target the vaccine antigen to the CC Motif Chemokine Receptor 6 (CCR6) …